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Animals Using a Biological Assay. Each Drontal Plus Taste Tabs Tablet for Large Dogs contains 136. Freedom of Information Summary FOI NADA 133-953 Vercom Paste febantel and praziquantel. Use with caution in sick or debilitated cats. Oral ingestion or exposure should be avoided. Use with caution in heartworm positive cats. The cats enrolled in the field study were heartworm antigen and antibody negative prior to entering the study. In a laboratory study, cats artificially infected with adult heartworms and treated with Profender Topical Solution had fewer worms recovered than the placebo control group.

Repeat dose in 2 weeks

Taste Tabs information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. Broad Spectrum Dewormer Tablets for Cats and Kittens are scored for easy breakage. Bayer HealthCare, Bayer Inc. There was no evidence of carcinogenic effect in laboratory animal models.

Praziquantel is an isoquinoline cestocide

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Cats maintained under conditions of constant exposure to parasite infections should have a follow-up fecal examination within 2 to 4 weeks after the first treatment. Domestic dogs living in E. multilocularis endemic areas that roam freely with the opportunity to catch wild rodents are at risk for infection. Pet owners should be advised on how to minimize this risk. Proper restraint of roaming dogs should be encouraged, along with regular treatment with Droncit Injectable solution, following the dosing schedule aforementioned and precautions indicated below.

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Hookworms are small whitish or reddish-brown worms less than one inch in length that live in the intestinal tract and feed on blood. Cats can become infected with hookworms by swallowing infected larvae while grooming or when larvae from the environment burrow through the skin. Cats infected with hookworms may have poor physical condition, dull haircoat, and reduced body weight and diarrhea, sometimes with the presence of dark blood. Echinococcus multilocularisis a tapeworm species usually found in wild canids, including foxes, coyotes and wolves. The parasite has also been identified in domestic dogs and cats and is potentially a serious public health concern because it may infect humans.



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Symptoms of overdosage 10 to 20 times the labeled dosage rate in adult cats included vomition, depression, muscle tremors and incoordination. Deaths occurred in 5 of 8 cats treated subcutaneously and in all 8 injected intramuscularly at doses greater than 20 times the label rate. Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Broad Spectrum Wormer tablets will remove Tapeworms Dipylidium caninum, Taenia taeniaeformis Hookworms Ancylostoma tubaeforme and Large Roundworms Toxocara cati in kittens and cats. Lieby PD, Carney WP and Woods CE. 1970. Studies on Sylvatic Echinococcosis, Ill. Host Occurrence and Geographic Distribution of Echinococcus multilocularis in the North Central United States. J. Parasit. 566: 1141-1150. Not for human use. Keep out of reach of children. Plus Tablets and dogs treated at intervals greater than 28 days may shed eggs in the feces after treatment. The animal should be held in the clinic during this interval and all feces should be incinerated or autoclaved. Enrofloxacin is bactericidal and exerts its antibacterial effect by inhibiting bacterial DNA gyrase a type II topoisomerase thereby preventing DNA supercoiling and replication which leads to cell death. 1 Enrofloxacin is active against Gram-negative and Gram-positive bacteria. Since pyrantel is usually taken in one dose, you are not likely to miss a dose. What happens if I overdose? Local irritation or swelling at the site of subcutaneous injections have been reported for cats. Soulsby EJL. 1982. Helminths, Arthropods and Protozoa of Domesticated Animals. Hepatosplenic schistosomiasis patients with moderate to severe liver dysfunction Child-Pugh B and C: Usual dose should be used with caution. Dose Tolerance Study in Cats: Profender Topical Solution was applied topically one time to young cats at 10X the recommended label use rate. Two cats salivated. Another cat exhibited tremors and lethargy. These signs were self-limiting. Plus on pregnant animals have not been determined. Biltricide praziquantel is an anthelmintic, or anti-worm, medication used to treat infections caused by Schistosoma worms, which enter the body through skin that has come into contact with contaminated water. Schistosoma worms are found in Africa, South America, Middle Eastern countries, the Carribean, and parts of Asia. Biltricide is also used to treat infection with liver flukes, caused by a type of worm found in East Asia.



How should I take pyrantel?

Always consult a healthcare professional for medical advice. Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. Symptoms of overdosage 33. Homeida MM, Eltom IA, Sulaiman SM, Ali HM, Bennett JL "Tolerance of two brands of praziquantel. Dogs: Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus and for the removal and control of Echinococcus multilocularis. Cats: Taenia taeniaeformis and Dipylidium caninum. Praziquantel should not be used to treat parasitic infections in the eye. No clinical signs of toxicity or changes in clinical pathology parameters were observed. No articular cartilage lesions were observed inthe stifle joints at any dose level at 2 days and 9 days following 15 days of drug administration. Tablets may be given directly by mouth or offered in a small amount of the food. Do not withhold food from the cat prior to or after treatment. Current guidelines should be consulted for additional information. Gastrointestinal side effects have included nausea, vomiting, diarrhea, abdominal cramps. Nervous system side effects have included dizziness, drowsiness, insomnia, and headache.



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Safety has not been established in patients younger than 4 years. Incidental lameness of short duration was observed in all groups, including the saline-treated controls. Plus Tablet for Large Dogs contains 136. Not intended for use in kittens less than six 6 weeks of age. Strict hygienic precautions should be taken when handling dogs or feces suspected of harboring E. multilocularis. Results obtained in the laboratory and clinical studies indicate small numbers of hookworm or roundworm eggs may be passed in the feces for up to 7 days after treatment although the worms themselves were eliminated. Large roundworms and hookworms pass eggs in the feces of the cat that can only be observed with the aid of a microscope. Often, it was unclear if praziquantel, an endogenous reaction to parasites dying from the drug, or symptoms of the infestation caused the reported side effects. All adverse reactions were self-limiting. Praziquantel should be taken with a meal. Praziquantel may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. There are no known contraindications against the use of praziquantel or pyrantel pamoate in dogs. Laboratory effectiveness studies: One cat died 10 days after receiving Profender Topical Solution. The necropsy showed chronic active cholangiohepatitis. While the use of the drug did not appear to be the direct cause of death, treatment with the drug cannot be ruled out as a contributing factor See . One cat treated with a vehicle placebo formulation minus the active ingredients showed salivation, gagging, lethargy and a swollen tongue. Drontal, Bayer and Bayer Cross are registered trademarks of Bayer AG, used under license.



Drontal adult dosage

Current guidelines should be consulted for additional information. What other drugs will affect praziquantel? Tablets. The majority of tapeworms, however, are digested and are not found in the feces after treatment. To assure proper dosage, weigh the cat prior to treatment. Select the number of whole or partial tablets needed for the cat from the following table. To ensure the entire contents of the tube are administered, place the tip of the tube on the skin and squeeze the entire contents directly onto the skin. Lift tube away from the skin before releasing pressure on the tube. Each tablet size is available in bottles of 50 puppies and small dogs, medium sized dogs or 30 large dogs. Some pyrantel side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Seek emergency medical attention. What should I avoid while taking pyrantel?



Prescribing information for drontal

Laboratory efficacy and clinical studies conducted with Drontal Plus Anthelmintic Tablets demonstrate that each of the three active ingredients act independently without interference. The combined tablet formulation provides a wide spectrum of activity against the indicated species of intestinal helminths. Data from these studies demonstrated Profender Topical Solution is safe and effective for the treatment and control of hookworm infections caused by Ancylostoma tubaeforme adults, immature adults, and fourth stage larvae roundworm infections caused by Toxocara cati adults and fourth stage larvae and tapeworm infections caused by Dipylidium caninum adults and Taenia taeniaeformis adults. Tablets contain three active ingredients having different modes of action and spectra of activity. Praziquantel is active against cestodes tapeworms. Praziquantel is absorbed, metabolized in the liver and excreted in the bile. Upon entering the digestive tract from the bile, cestocidal activity is exhibited. 1 Following exposure to praziquantel, the tapeworm loses its ability to resist digestion by the mammalian host. Because of this, whole tapeworms, including the scolices, are very rarely passed after administration of praziquantel. In many instances only disintegrated and partially digested pieces of tapeworms will be seen in the stool. The majority of tapeworms are digested and are not found in the feces. Store at room temperature away from moisture and heat. What happens if I miss a dose? Mazzotti reaction after treatment with ivermectin, praziquantel, and albendazole for presumptive schistosomiasis and strongyloidiasis. Six days after receiving standard empiric therapy, he developed epigastric pain, vomiting, and urticaria. This progressed in 4 hours and included fever, general myalgia, and edema of the face, lower extremities, and penis accompanied by urticaria of the arms, legs, and trunk. He was diagnosed with a Mazzotti reaction and treated with methylprednisolone; symptoms subsided within 12 hours. Cats maintained under conditions of constant exposure to parasite infections should have a follow-up fecal exam within 2 to 4 weeks after the first treatment. DOSAGE: The presence of parasites should be confirmed by laboratory fecal examination. Weigh the animal before treatment. Administer the proper dosage as specified in the following table as a single oral treatment. Subcutaneous injection can cause a transient local tissue reaction that may result in trim loss of edible tissue at slaughter. PD Carney WP and Woods CE. 1970. Studies on Sylvatic Echinococcosis, Ill. Host Occurrence and Geographic Distribution of Echinococcus multilocularisin the North Central United States. J. Parasit. 566: 1141-1150. Dermatologic side effects have included skin rashes. Following exposure to praziquantel, the tapeworm loses its ability to resist digestion by the mammalian host. Because of this, whole tapeworms, including the scolices, are very rarely passed after administration of praziquantel. In many instances only disintegrated and partially digested pieces of tapeworms will be seen in the stool. The majority of tapeworms are digested and are not found in the feces. Side effects varied according to dose and duration of praziquantel therapy. Side effects depended on parasite species, extent of infestation, infection duration, and parasite location in the body. Anthelmintic Tablets. Dogs receiving up to 5 times the label dosage 35 mg praziquantel, 35 mg pyrantel pamoate and 179 mg febantel per kg of body weight for 3 consecutive days 3 times the label duration showed clinical signs of vomition and non-formed stools. One dog receiving a 3 times labeled dose had elevated SGPT, SGOT, CPK and GGT readings outside of normal range at 6 days post-treatment. Do not drive or operate heavy machinery on the day of and during the 24 hours after treatment; the drug may cause dizziness or drowsiness. The presence of tapeworms is indicated by the observance of tapeworm segments passed in the cat's feces. Tapeworm segments are white, pinkish-white or yellow-white in colour and are similar in size and shape to flattened grains of rice. The segments are most frequently observed lying on a freshly passed stool. Segments may also be found on the hair around the anus of the animal, or on the animal's bedding. Cats become infected with tapeworms after eating fleas or small animals mice and other rodents which may be infected with tapeworm larvae. This list is not complete and other drugs may interact with praziquantel. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.



Protect from direct sunlight

The safety index has been derived from controlled safety evaluations, clinical trials and prior approved use in foreign countries. Dosages of 5 times the labeled rate at 14 day intervals to dogs as young as 4 weeks did not produce signs of clinical toxicity following either intramuscular or subcutaneous injections. No significant clinical chemistry, hematological, cholinesterase or histopathological changes occurred. Oral Safety Studies in Cats: Profender Topical Solution was administered orally at the recommended topical dose to young adult cats. The cats exhibited salivation, vomiting, tremors, abnormal gait, abnormal respiration and weight loss. These signs were self-limiting. Plus Tablets for removal of E. multilocularis is the same as that indicated for the removal of the other tapeworm species listed on the label. Laboratory efficacy studies have demonstrated the recommended dosage is 100% effective. One dog receiving a 3 times labeled dose had elevated SGPT, SGOT, CPK and GGT readings outside of normal range at 6 days post-treatment. RETREATMENT: For those animals living where reinfections are likely to occur, clients should be instructed in the steps to optimize prevention; otherwise, retreatment may be necessary. This is true in cases of Dipylidium caninum where reinfection is almost certain to occur if fleas are not removed from the animal and its environment. In addition, for control of Echinococcus multilocularis, a program of regular treatment every 21 to 26 days may be indicated see E. multilocularis section below. Certain parasites such as tapeworms and large roundworms are transmitted to the cat after they eat infected rodents. Controlling the predatory habits of cats from catching and eating rodents will prevent these parasite infections. Cats become infected with tapeworms after eating fleas or small mammals rabbits, mice which may be infected with tapeworm larvae. The adult tapeworm is small 1-4mm and resides in the intestinal tract of the definitive host wild or domestic canids. Eggs from the adult tapeworm are shed in the feces. Rodents such as mice and voles serve as the intermediate host. Eggs ingested by rodents develop in the liver, lungs and other organs to form multilocular cysts. The life cycle is completed after a canid consumes a rodent infected with cysts. Larvae within the cyst develop into adult tapeworms in the intestinal tract of the canid.



All adverse reactions were self-limiting

Tablets in a clinical field study did not exhibit any drug related side effects. A temporary loss of appetite was reported for one cat and transient loose stools were observed in a second cat. Hildreth MB Johnson MD and Kazacos KR. 1991. A Zoonosis of Increasing Concern in the United States. Compendium for Cont. Ed. 135: 727-740. F; however such exposure should be minimized. When schistosomiasis or fluke infection is associated with cerebral cysticercosis, hospitalization of the patient for the duration of therapy is recommended. Cerner Multum, Inc. "Australian Product Information. Every effort has been made to ensure the accuracy of the Drontal information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert. The long-term effects on articular joint cartilage have not been determined in pigs above market weight. Plus Tablets are safe and efficacious for the removal of the parasite species indicated on the label when used as directed. Roundworms and hookworms are controlled by maintaining the cat's environment free of infective eggs and larvae. Feces and soiled litter should be removed on a daily basis to prevent build-up of eggs and larvae in the environment. Droncit praziquantel Injectable Cestocide may be administered by either the subcutaneous or intramuscular route to dogs and cats. The intramuscular route may be preferred in dogs due to a brief period of pain that occasionally follows subcutaneous administration. Anaphylactoid reactions were not observed in clinical trials. However, as with any drug an anaphylactoid reaction can occur with this product and should be treated symptomatically if it occurs. Of those, 606 received a single treatment with Profender Topical Solution. The life cycle of the parasite is based on a predator-prey relationship, as depicted above. The inflammatory reaction produced by antigenic substances released from dying cysts frequently involved increased intracranial pressure, seizures, severe headaches, nausea, and vomiting. In areas where Taenia solium was endemic, these reactions may occur as the result of undiagnosed cysticercosis in patients being treated for other parasitic infections. The duration of the reaction differs among patients. Delayed reactions have been reported. Plus Anthelmintic Tablets in the clinical field studies exhibited drug-related side effects. Take this medication with a full glass 8 ounces of water.



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Campbell WC. 1986. The Chemotherapy of Parasitic Infections. J. Parasit. Some praziquantel side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Diagnosis of E. multilocularis in canids is difficult. The adult tapeworm produces no clinical signs of infection. Tapeworm segments proglottids are usually not observed in the feces. E. multilocularis eggs, observed using microscopic fecal examination procedures, are similar in appearance to those of common species such as Taenia pisiformis. Assistance in the diagnosis of E. multilocularismay be available from a state veterinary diagnostic laboratory.

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This parasite poses a serious public health problem because of the possibility for human involvement in the life cycle. If eggs shed by an infected canid are accidentally ingested, a highly pathogenic condition Alveolar Hydatid Disease results from development of the cyst stage in humans. Diagnosis of E. multilocularis in canids is difficult. The adult tapeworm produces no clinical signs of infection. Tapeworm segments proglottids are usually not observed in the feces. E. multilocularis eggs, observed using microscopic fecal examination procedures, are similar in appearance to the common taeniid species of canids such as Taenia pisiformis.

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Tapeworms transmitted by fleas will likely recur unless measures are taken to control fleas. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. An injection site study conducted in feeder calves demonstrated that the formulation may induce a transient reaction in the subcutaneous tissue and underlying muscle. No painful responses to administration were observed.

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Dogs infected with E. multilocularis should be treated to prevent exposure of humans to infective eggs and to reduce perpetuation of the parasite's life cycle. Ciferri F "Delayed CSF reaction to praziquantel. You should not take this medicine if you are allergic to praziquantel, or if you have take rifampin Rifadin, Rifater, Rifamate in the last 4 weeks.

Plus Tablets contain three active ingredients having different modes of action and spectra of activity. Praziquantel is active against cestodes tapeworms. Praziquantel is absorbed, metabolized in the liver and excreted in the bile. Upon entering the digestive tract from the bile, cestocidal activity is exhibited. 1 Following exposure to praziquantel, the tapeworm loses its ability to resist digestion by the mammalian host. Because of this, whole tapeworms, including the scolices, are very rarely passed after administration of praziquantel. In many instances only disintegrated and partially digested pieces of tapeworms will be seen in the stool. The majority of tapeworms are digested and are not found in the feces.

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